6/25/2026

My Insulin Switch Story: From Glargine to Tresiba

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Insulin

In diabetes treatment, the choice of basal insulin directly impacts the quality of daily life. This time, I've compiled my personal experience with switching insulin preparations and a comparison between them.

Comparing the Preparations

Feature Glargine (Lantus, etc.) Tresiba (Degludec)
Mechanism of Action Once-daily, consistent effect Ultra-long acting (42+ hours)
Dosing Time Flexibility Same time each day is preferred Tolerant of minor deviations

The Value of "Peace of Mind" from My Experience

Initially, I used Glargine during my hospitalization, but after discharge, my doctor at the outpatient clinic suggested switching to Tresiba. While Tresiba's drug cost is slightly higher, the "peace of mind" it offers—knowing that its effects overlap even if dosing times are slightly off, and there's no anxiety about the effect wearing off—is, I believe, worth more than the price difference.

Important Considerations When Using Tresiba

Key Points to Be Aware Of:

  • Prolonged Hypoglycemia: Due to its very long-acting nature, if hypoglycemia (low blood sugar) occurs, it may take a longer time for blood glucose levels to return to normal.
  • Injection Site Management: As this medication remains in the body for an extended period, it's crucial to properly rotate injection sites and protect the subcutaneous tissue.

*This content is based on personal experience. Any changes to medication or administration methods should always be discussed and decided upon with your primary physician.

ℹ️ Note for International Readers:
Portion Sizes: The food portions and nutritional data featured in this blog are based on standard Japanese serving sizes, which may be smaller than typical Western servings.
Net Carb Calculation: Net Carbs = Total Carbs - Dietary Fiber.

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*Medical Disclaimer: The content on this blog represents the author's personal records for informational purposes only. Always consult with your doctor.

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